abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. This article reviews the epidemiology, risk factors, pathogenesis, and prognosis of CRC with special emphasis on advances in the management of CRC over the past decade. METHOD...

journal_title：International journal of colorectal disease

authors： Ahmed S,Johnson K,Ahmed O,Iqbal N

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Cancer survival is related not only to primary malignancy but also to concomitant nonmalignant diseases. The aim of this study was to investigate the prognostic capacity of four comorbidity indices [the Charlson comorbidity index (CCI), the Elixhauser method, the National Institute on Aging (NIA) and Natio...

journal_title：International journal of colorectal disease

authors： Marventano S,Grosso G,Mistretta A,Bogusz-Czerniewicz M,Ferranti R,Nolfo F,Giorgianni G,Rametta S,Drago F,Basile F,Biondi A

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Whether race affects the natural history of Crohn's disease is a matter of debate. The aim of the current study was to evaluate the differences in surgical outcomes between African-American (AA) and Caucasian (C) Crohn's patients undergoing surgery at a tertiary care referral center. METHODS:W...

journal_title：International journal of colorectal disease

authors： Griglione N,Yarandi S,Srinivasan J,Ahearn T,Dhere T

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonic diverticulitis shows a high recurrence rate, but the role of faecal markers in predicting recurrence is unknown. The aim of this study was to investigate the role of faecal calprotectin (FC) in predicting recurrence of diverticulitis. PATIENTS/METHODS:A prospective cohort study was performe...

journal_title：International journal of colorectal disease

authors： Tursi A,Elisei W,Picchio M,Brandimarte G

更新日期：2014-08-01 00:00:00

abstract：INTRODUCTION:Debate persists regarding the relationship between mucin expression and outcome in colon cancer. This arises due to discrepancy in the definition of mucinous adenocarcinoma and the combination of both colon and rectal cancers in analyses. This study examines the relationship between increased mucin product...

journal_title：International journal of colorectal disease

authors： Hogan J,Burke JP,Samaha G,Condon E,Waldron D,Faul P,Coffey JC

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Anastomotic leakage (AL) after total mesorectal excision (TME) for rectal cancer is suspected to alter function. However, very few reports have been devoted to this problem. The aim of this study was to assess the influence of AL on function and quality of life (QoL) after laparoscopic TME for cancer. METHODS:...

journal_title：International journal of colorectal disease

authors： Mongin C,Maggiori L,Agostini J,Ferron M,Panis Y

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Pelvic radiotherapy may lead to changes of anorectal function resulting in incontinence-related complaints. The aim of this study was to systematically review objective findings of late anorectal physiology and mucosal appearance after irradiation for prostate cancer. METHODS:MEDLINE, EMBASE, and the Cochrane ...

journal_title：International journal of colorectal disease

authors： Krol R,Smeenk RJ,van Lin EN,Yeoh EE,Hopman WP

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Whether the introduction of extralevator abdominoperineal excision (ELAPE) improves survival and safety remains controversial. We conducted a systematic review and meta-analysis of all comparative studies to define the efficacy and safety of ELAPE and standard abdominoperineal excision (APE). MATERIALS AND MET...

journal_title：International journal of colorectal disease

authors： Yu HC,Peng H,He XS,Zhao RS

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Several studies have confirmed that laparoscopic colorectal surgery results in improved early post-operative outcomes. Nevertheless, conventional laparoscopic approach and instruments have several limitations. Robotic approach could potentially address of many of these limitations. OBJECTIVES:This review ai...

journal_title：International journal of colorectal disease

authors： Aly EH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) of the rectum are rarely found, and radical surgery such as abdominoperineal resection would be necessary for large rectal GIST. On the other hand, therapy for GIST has changed significantly with the use of imatinib. Neoadjuvant imatinib therapy may reduce tumor size a...

journal_title：International journal of colorectal disease

authors： Fujimoto Y,Akiyoshi T,Konishi T,Nagayama S,Fukunaga Y,Ueno M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Infections are the leading cause of morbidity and mortality after colorectal surgery. Obesity is a well-known risk factor for wound infection, but it does not seem to increase the risk of other infectious complications. The aim of this study was to look for a relationship between the fatty tissue metabolism ...

journal_title：International journal of colorectal disease

authors： Ortega-Deballon P,Duvillard L,Scherrer ML,Deguelte-Lardière S,Bourredjem A,Petit JM,Bonithon-Kopp C,AGARIC Study group.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Laterally spreading tumors (LSTs) are being increasingly reported nowadays. The aims of this study were to analyze the clinicopathologic characteristics and to identify the risk factors of malignancy in patients with LSTs by morphological subclassification. PATIENTS AND METHODS:The authors retrospectiv...

journal_title：International journal of colorectal disease

authors： Kim KO,Jang BI,Jang WJ,Lee SH

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Aberrant activation of the Wnt/β-catenin pathway plays a major role in the development of colorectal carcinoma (CRC). Axin 2 is a key protein of this pathway and is upregulated in CRC. Here, we investigated RNA- and protein expression of axin 2 in CRC tissues at the single cell level. Moreover, the association ...

journal_title：International journal of colorectal disease

authors： Schaal U,Grenz S,Merkel S,Rau TT,Hadjihannas MV,Kremmer E,Chudasama P,Croner RS,Behrens J,Stürzl M,Naschberger E

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The UK government target expects all suspected colorectal cancer (CRC) patients to be seen within the Two-Week Referral (TWR) system made by general practitioners. These guidelines originally derived from only level 5 evidence. However, this has significant impact on the workload for colorectal surgeons. The ai...

journal_title：International journal of colorectal disease

authors： Padwick RT,Bajwa AA,Shaw A,Leung E,Francombe J,Stellakis ML

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Tumour-associated macrophages have been shown to promote proliferation, angiogenesis and metastasis in several carcinomas. The effect on colon cancer has not yet been clarified. Furthermore, Kupffer cells in the liver might initiate the formation of metastases by directly binding tumour cells. METHODS:An ortho...

journal_title：International journal of colorectal disease

authors： Kruse J,von Bernstorff W,Evert K,Albers N,Hadlich S,Hagemann S,Günther C,van Rooijen N,Heidecke CD,Partecke LI

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:When severe chronic pelvic pain, constipation, and bloating are due to dense pelvic adhesions fixing the sigmoid loops, patients may be offered the option of sigmoid colectomy. This study examines the effectiveness of colectomy in the treatment of such patients. METHODS:Patients were identified from a sur...

journal_title：International journal of colorectal disease

authors： Jarrar A,Church J

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:The present study was performed to get a better insight in the incidence of anastomotic leakage leading to reintervention when using the C-seal: a biodegradable sheath that protects the stapled colorectal anastomosis from leakage. METHODS:The C-seal is a thin walled tube-like sheath that forms a protective she...

journal_title：International journal of colorectal disease

authors： Morks AN,Havenga K,ten Cate Hoedemaker HO,Leijtens JW,Ploeg RJ,C-seal Study Group.

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Prior international datasets have demonstrated equivocal results in the rate of surgical procedures for the treatment of Crohn's disease (CD) following the introduction of biologic medications. The first biologic medication licensed for use in the Republic of Ireland (ROI) was infliximab in 1999. The curre...

journal_title：International journal of colorectal disease

authors： Burke JP,Velupillai Y,O'Connell PR,Coffey JC

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Although advances in multimodal treatment have led to prolongation of survival in patients after resection of colorectal liver metastasis (CRC-LM), most patients develop recurrence, which is often confined to the liver. Repeat hepatic resection (RHR) may prolong survival or even provide cure in selected pa...

journal_title：International journal of colorectal disease

authors： Neeff HP,Drognitz O,Holzner P,Klock A,Bronsert P,Hopt UT,Makowiec F

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-α) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic ...

journal_title：International journal of colorectal disease

authors： Hozumi H,Hokari R,Kurihara C,Narimatsu K,Sato H,Sato S,Ueda T,Higashiyama M,Okada Y,Watanabe C,Komoto S,Tomita K,Kawaguchi A,Nagao S,Miura S

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and ...

journal_title：International journal of colorectal disease

authors： Chen WF,Gao WD,Li QL,Zhou PH,Xu MD,Yao LQ

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:The purposes of this study were to assess the working definition of a colorectal anastomotic leak among colorectal surgeons and to survey the current approach to investigation and management of a patient with a suspected anastomotic leak. METHODS:Online survey consisting of nine questions regarding the definit...

journal_title：International journal of colorectal disease

authors： Adams K,Papagrigoriadis S

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Lower gastrointestinal bleeding represents 20 % of all gastrointestinal bleedings. Interventional radiology has transformed the treatment of this pathology, but the long-term outcome after selective embolization has been poorly evaluated. The aim of this study is thus to evaluate the short-term and long-term...

journal_title：International journal of colorectal disease

authors： Rossetti A,Buchs NC,Breguet R,Bucher P,Terraz S,Morel P

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:One of the main uses of robotic assisted abdominal surgery is the mesorectal excision in patients with rectal cancer. The aim of the present study is to analyse the learning curve for robotic assisted laparoscopic resection of rectal cancer. PATIENTS AND METHODS:We included in our study 43 consecutive rec...

journal_title：International journal of colorectal disease

authors： Jiménez-Rodríguez RM,Díaz-Pavón JM,de la Portilla de Juan F,Prendes-Sillero E,Dussort HC,Padillo J

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:The usefulness of restaging by magnetic resonance imaging (MRI) after chemoradiotherapy (CTx/RTx) in patients with locally advanced rectal cancer has not yet been established, mostly due to the difficult differentiation between viable tumor and fibrosis. MRI with dynamic contrast-enhanced (DCE) sequences may be...

journal_title：International journal of colorectal disease

authors： Alberda WJ,Dassen HP,Dwarkasing RS,Willemssen FE,van der Pool AE,de Wilt JH,Burger JW,Verhoef C

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The duodenum as primary site for gastrointestinal stromal tumors (GISTs) is rare and mitotic rate, tumor size, type of mutation and number of chromosomal aberrations have prognostic implications. METHODS:We analyzed the outcome of 13 patients with duodenal GISTs who underwent surgical tumor resection. Either s...

journal_title：International journal of colorectal disease

authors： Beham A,Schaefer IM,Cameron S,von Hammerstein K,Füzesi L,Ramadori G,Ghadimi MB

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The current study aimed to compare the oncologic outcome and pattern of metastasis after abdominoperineal resection (APR) and low anterior resection (LAR) treating lower rectal cancer. METHODS:A total of 804 patients undergoing curative resection (R0) were enrolled prospectively. The APR and LAR groups (n = 40...

journal_title：International journal of colorectal disease

authors： Kim JC,Yu CS,Lim SB,Kim CW,Kim JH,Kim TW

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Conventional haemorrhoidectomy (CH) is well known to cause significant post-operative pain and delayed return to daily activities. Both surgical wounds and sphincterial apparatus spasms are likely responsible for the pain. In this study, we evaluated the role of glyceryl trinitrate ointment (GTN) in reduci...

journal_title：International journal of colorectal disease

authors： Franceschilli L,D'Ugo S,de Luca E,Cadeddu F,Milito G,di Lorenzo N,Gaspari AL,Sileri P

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Dendritic cell (DC)-based cancer vaccine represents a promising immunotherapy against cancer. There has been recent evidence which have suggested that toll-like receptor (TLR) ligands may be critical for DC preparation; this was usually omitted in the past. Our study is designed to investigate if the vaccinatio...

journal_title：International journal of colorectal disease

authors： Hong X,Dong T,Hu J,Yi T,Li W,Zhang Z,Lin S,Niu W

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Although small rectal carcinoid tumors can be treated using local excision, complete resection can be difficult because tumors are located in the submucosal layer. We evaluate the factors associated with pathologically complete local resection of rectal carcinoid tumors. METHODS:Data were analyzed of 161 patie...

journal_title：International journal of colorectal disease

authors： Son HJ,Sohn DK,Hong CW,Han KS,Kim BC,Park JW,Choi HS,Chang HJ,Oh JH

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the possible association between tumor necrosis factor-α (TNF-α) levels and defects in the activated protein C (APC) system as a determinant of venous thromboembolism (VTE) in metastatic colorectal cancer patients (mCRC) undergoing chemotherapy. METHODS:TNF-α levels...

journal_title：International journal of colorectal disease

authors： Ferroni P,Riondino S,Portarena I,Formica V,La Farina F,Martini F,Massimiani G,Palmirotta R,Guadagni F,Roselli M

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Matrix metalloproteinases (MMPs) have repeatedly been shown to play a very active role in extracellular matrix degradation associated with tumor invasion and metastasis. Tissue inhibitors of MMPs (TIMPs) are well-known for their ability to inhibit MMP activity thereby inhibiting malignant progression. Inos...

journal_title：International journal of colorectal disease

authors： Kapral M,Wawszczyk J,Jurzak M,Hollek A,Węglarz L

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to identify rates and factors associated with permanent diversion following restorative proctosigmoidectomy for rectal cancer when complicated by an anastomotic leak. DESIGN:This study is a retrospective review. SETTING:The setting of this study is a tertiary referral hospital...

journal_title：International journal of colorectal disease

authors： Ogilvie JW Jr,Dietz DW,Stocchi L

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:The aim of the present study was to determine selection criteria for patients with stage IV colorectal cancer (CRC) who were likely to show survival benefits of metastasectomy. METHODS:Clinicopathological data of 119 patients with stage IV CRC who underwent primary CRC resection were retrospectively reviewed. ...

journal_title：International journal of colorectal disease

authors： Shimomura M,Okajima M,Hinoi T,Egi H,Takakura Y,Kawaguchi Y,Tokunaga M,Adachi T,Tashiro H,Ohdan H

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:The oncological results of close distal resection margins (DM) have been mixed due to variations in perioperative treatment protocols and surgical expertise. With the increased application of sphincter-saving surgery in the management of rectal cancer, "close shave" DM is an increasingly encountered phenomenon....

journal_title：International journal of colorectal disease

authors： Lim JW,Chew MH,Lim KH,Tang CL

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Bilobar colorectal liver metastases (CRLM) are often considered incurable or associated with poor prognosis even after R0 resection. In this single-center study, we evaluate the impact of CRLM spreading on recurrence-free survival (RFS) and cancer-specific overall survival (CSS) after R0 resection of CRLM with ...

journal_title：International journal of colorectal disease

authors： Homayounfar K,Bleckmann A,Conradi LC,Sprenger T,Beissbarth T,Lorf T,Niessner M,Sahlmann CO,Meller J,Becker H,Liersch T,Ghadimi BM

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Colon anastomotic leakage remains both a frequent and serious complication in gastrointestinal surgery. External coating of colonic anastomoses has been proposed as a means to lower the rate of this complication. The aim of this review was to evaluate existing studies on external coating of colonic anastomoses....

journal_title：International journal of colorectal disease

authors： Pommergaard HC,Achiam MP,Rosenberg J

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Crohn's disease (CD) commonly recurs after surgery, and a number of patients need repeated surgery, especially smokers and those with repeated surgeries or penetrating disease. Whether infliximab prevents postsurgical recurrence in high-risk CD remains unknown. In the present pilot open-labeled study, we invest...

journal_title：International journal of colorectal disease

authors： Sakuraba A,Sato T,Matsukawa H,Okamoto S,Takaishi H,Ogata H,Iwao Y,Hibi T

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:High level of microsatellite instability (MSI-H) in colorectal cancer (CRC) is caused by the inactivation of mismatch repair (MMR) genes; however, it is unknown for tumors with low level MSI (MSI-L). The protein complex involving MSH3 preferentially recognizes insertion/deletion loops (IDLs) of two to eight bas...

journal_title：International journal of colorectal disease

authors： Plaschke J,Preußler M,Ziegler A,Schackert HK

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:The transplantation of neural crest derived stem cells (NCSC) is a potent alternative for the treatment of Hirschsprung's disease (HSCR). Cells to be transplanted should find an appropriate microenvironment to survive and differentiate. Influences of HSCR-smooth-muscle-protein extracts upon isolated myente...

journal_title：International journal of colorectal disease

authors： Hagl CI,Rauch U,Klotz M,Heumüller S,Grundmann D,Ehnert S,Subotic U,Holland-Cunz S,Schäfer KH

更新日期：2012-06-01 00:00:00